Friday, 17 December 2021 18:47

Schizophrenia is a chronic and severe mental illness that affects approximately one percent of the adult population

Schizophrenia Schizophrenia pixabay

Symptoms include auditory hallucinations, delusions, social withdrawal, apathy and disorganized thinking. The disorder has been found to be up to 90 percent heritable in some studies, while environmental factors play a role as well.

There are medications used to treat schizophrenia symptoms but they can have significant side effects and patients frequently discontinue their use. Some patients also receive electroconvulsive therapy (ECT), which has benefits for short-term treatment of severe symptoms but also has potential adverse effects and does not always work for this condition.

In an article published in Translational Psychiatry , researchers from China present data on an uncontrolled study of valproicacid, a mood-stabilizing drug used clinically to treat mania and epilepsy. This retrospective analysis of data from 97 http://mzcr.cz/Legislativa/dokumenty/informacni-seminar-k-pripravovanemu-programu-zdravi-v-ramci-nadchazejiciho-progr_15880_3855_8.html child and adolescent patients with schizophrenia found that valproic acid treatment was associated with a significant reduction in symptoms, especially hallucinations and delusions. The researchers suggest that further research on proven safe treatments is needed to help manage challenging child psychiatric disorders, such as schizophrenia.

Valproic acid has been shown to have effects on the dopamine reward system implicated in schizophrenia, which may explain why it could be effective for psychotic symptoms. In this study, child psychiatrists at 39 hospitals across China assessed child and adolescent patients aged 6-18 years old who were diagnosed with chronic or florid (acutely intense) paranoid schizophrenia using ChineseClassification of Mental Disorders, third edition (CCMD-3) criteria. Patients were started on valproic acid at a dose of 500 mg/day and then titrated up or down as needed. The average dose was 1,023 mg/day.

The researchers found that the percentage of patients with a 50 percent or greater reduction in symptoms was significantly higher in the valproic acid group than in the control group (74.5 percent vs. 36.8 percent). In addition, the number of patients who had a complete remission of symptoms was also higher in the valproic acid group (27.1 percent vs. 3.2 percent). There were no significant differences between the two groups in terms of adverse effects.These findings suggest that valproic acid may be a safe and effective treatment for child and adolescent patients with schizophrenia. The study was uncontrolled and did not have a placebo group, so further research is needed to confirm these results. However, this study provides evidence that there may be other safe and effective treatments for child psychiatric disorders beyond medications and ECT. This could provide hope for children and families who are struggling with these devastating disorders.

  • Why Your Amazon Ads Are Underperforming - Key Insights and Solutions
    Why Your Amazon Ads Are Underperforming -  Key Insights and Solutions

    Amazon advertising is a vital tool for sellers to enhance their visibility and increase sales. Yet, many find their ads underperforming, leading to wasted budgets and missed opportunities. Understanding the common pitfalls and how to address them can transform your campaign performance. For more in-depth guidance, consider exploring ACosbot.com and the Ultimate Amazon PPC Guide.

  • BMW M3 - Updated Sports Sedan and Wagon for Australia
    BMW M3 - Updated Sports Sedan and Wagon for Australia

    In the fourth quarter of 2024, the updated BMW M3 series will debut in the Australian market, offering more power for all-wheel drive models and new infotainment technologies. BMW announced that the local 2025 M3 model lineup will be revealed "in due course." Currently available models include the base manual sedan, rear-wheel drive Competition sedan, and all-wheel drive Competition xDrive sedan and wagon.

  • Milan Airport Transfers - A Stress-Free Gateway to Your Winter Wonderland
    Milan Airport Transfers - A Stress-Free Gateway to Your Winter Wonderland

    Winter in Milan brings not only a festive atmosphere but also the anticipation of thrilling ski adventures in the nearby Alpine slopes. For those flying into Malpensa Airport with visions of pristine snowfields, Milan Airport Transfers offers a seamless, high-quality travel solution to kick off your vacation smoothly.

  • The Magic of Kenyan Safari Photography
    The Magic of Kenyan Safari Photography

    Kenya, with its stunning landscapes, diverse wildlife, and rich cultural heritage, is a photographer's paradise waiting to be explored. rom the majestic savannahs of the Maasai Mara to the picturesque beaches of Diani, Kenya offers a wealth of opportunities to capture luxury moments through the lens. Let's delve into the wonders of Kenya's photography scene, with a special focus on luxury safari experiences that showcase the beauty and splendor of this East African gem.

  • Ksenia Nauti - Crafting Bridal Dreams into Luxurious Reality
    Ksenia Nauti - Crafting Bridal Dreams into Luxurious Reality

    Every seasoned fashion journalist specializing in bridal trends has the opportunity to explore numerous design houses, yet few capture the essence of bridal elegance as precisely as the brand of Ksenia Nauti. Her boutique offers a range of wedding dresses, each crafted to fulfill the dreams of prospective brides with diverse tastes and visions.